Nasolabial filler is one of the most researched applications in aesthetic medicine. The evidence base is extensive and consistent: it is effective, well-tolerated, and carries a low rate of serious adverse events when properly administered. Click each study below to read the key findings.
1. Adverse Events Reported From Hyaluronic Acid Dermal Filler Injections to the Facial Region: A Systematic Review and Meta-Analysis (by the National Library of Medicine)
The nasolabial fold region experienced fewer adverse events — including swelling, lumpiness, and firmness — than the midface, perioral lines, or lips.
Nasolabial filler is one of the most researched applications in aesthetic medicine. The evidence base is extensive and consistent: it is effective, well-tolerated, and carries a low rate of serious adverse events when properly administered. Click each study below to read the key findings.
Read the full study here →
2. Safety and Efficacy Assessment of a Cross-linked Hyaluronic Acid Dermal Filler for Correction of Moderate-to-Severe Nasolabial Folds in Skin Types III and IV (by Dermatologic Therapy)
Adverse events were mild and transient across all 30 participants. Patient satisfaction scores ranged from 9 to 10 out of 10 at every follow-up point.
This prospective clinical study assessed hyaluronic acid filler for nasolabial fold correction across 30 patients, with follow-up assessments at 2, 12, and 24 weeks. Meaningful fold improvement was recorded at all three time points. No serious adverse events occurred during the full study period, and the filler demonstrated a high safety profile across a range of skin types.
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3. Efficacy of a New Hyaluronic Acid Dermal Filler on Nasolabial Folds Correction (by PMC)
Significant fold improvement was maintained across the 9-month follow-up period. No serious adverse events were reported. Local tolerance was rated as favourable.
In this randomised, investigator and subject-blinded trial, 45 participants with moderate-to-severe nasolabial folds were treated and followed for 9 months. The study assessed both efficacy and local tolerance at multiple time points. The results confirmed sustained improvement with a favourable safety profile, reinforcing the established clinical consensus on HA filler in this area.
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Taken together, this body of research supports nasolabial filler as a safe, effective treatment with a well-understood risk profile — not a claim that complications never occur, but that they are manageable, largely preventable, and predominantly mild when treatment is performed correctly.
